Primary ovarian failure
Asymptomatic postprocedural ovarian failure. E89.40 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2020 edition of ICD-10-CM E89.40 became effective on October 1, 2019.
2022 ICD-10-CM Diagnosis Code E28.3 E28.3 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail. The 2022 edition of ICD-10-CM E28.3 became effective on October 1, 2021. This is the American ICD-10-CM version of E28.3 - other international versions of ICD-10 E28.3 may differ.
Other primary ovarian failure 1 Female infertility due to diminished ovarian reserve 2 Ovarian failure (loss of ovary function) before age 40 3 Ovarian failure, primary 4 Premature ovarian failure 5 Primary ovarian failure 6 Secondary ovarian failure
Diagnosis Index entries containing back-references to E28.8: Amenorrhea N91.2 ICD-10-CM Diagnosis Code N91.2 Dysfunction ovary E28.9 ICD-10-CM Diagnosis Code E28.9 Hyperfunction ovarian E28.8 Hypergonadism ovarian E28.8 Hyperovarism E28.8 Hyperthecosis ovary E28.8
Listen to pronunciation. (oh-VAYR-ee-un FAYL-yer) A condition in which the ovaries stop working and menstrual periods stop before age 40. This can cause fertility problems and symptoms of menopause.
Diagnosis usually involves a physical exam, including a pelvic exam. Your provider might ask questions about your menstrual cycle, exposure to toxins, such as chemotherapy or radiation therapy, and previous ovarian surgery.
Primary ovarian insufficiency occurs when the ovaries stop functioning as they should before age 40. When this happens, your ovaries don't produce typical amounts of the hormone estrogen or release eggs regularly. This condition is also called premature ovarian failure and often leads to infertility.
Ovarian insufficiency is considered primary if the ovary fails to function normally in response to appropriate gonadotropin stimulation provided by the hypothalamus and pituitary. Ovarian insufficiency is considered secondary if the hypothalamus and pituitary fail to provide appropriate gonadotropin stimulation.
A simple means of distinguishing between the 2 conditions is to measure serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels (elevated in POF and low or normal in secondary ovarian failure).
It is defined by the association of amenorrhea, sex steroid deficiency and elevated (menopausal) levels of serum gonadotropins before the age of 40 years. It is not a rare condition; its incidence is estimated to be as great as 1 in 100 by the age of 40, and 1 in 1000 by the age of 20 years (1-5).
It is often caused by chromosomal abnormalities or damage from chemotherapy or radiation therapy. It is also associated with a premutation in the FMR1 gene for fragile X. Primary ovarian insufficiency may be associated with multiple endocrinopathies, including hypoparathyroidism and hypoadrenalism.
In secondary ovarian failure, the ovaries are normal but there is a problem getting hormone signals to them from the brain. This is usually caused by diseases of the pituitary gland or hypothalamus. Secondary ovarian failure may also be caused by certain medicines, too much exercise, or certain eating disorders.
What causes primary ovarian insufficiency?Autoimmune disorders (the body's own cells attack healthy tissue)Cancer treatments such as chemotherapy and radiation treatments.Genetic disorders including Turner Syndrome (genetic disorder involving an abnormality in one of a female's two X chromosomes) or Fragile X syndrome.More items...•
Primary ovarian insufficiency is a serious chronic disease that requires ongoing management in an integrated and collaborative manner.
Premature ovarian insufficiency (POI) is a common reproductive endocrine disorder defined by the cessation of ovarian function before the age of 40. POI is clinically characterized by oligomenorrhea or amenorrhea with increased gonadotrophins (FSH>25 IU/L) and decreased estradiol (E2) (1).
Currently, there are no treatments to reverse primary ovarian insufficiency. The goals of treatment are to: manage symptoms. lower your risk of developing osteoporosis and heart disease.