Stevens-Johnson syndrome is a rare but serious disorder that affects the skin, mucous membrane, genitals and eyes. The mucous membrane is the soft layer of tissue that lines the digestive system from the mouth to the anus, as well as the genital tract (reproductive organs) and eyeballs.
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are now believed to be variants of the same condition, distinct from erythema multiforme. SJS/TEN is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss.
Erythema Multiforme With Mucous Membrane Involvement and Stevens-Johnson Syndrome Are Clinically Different Disorders With Distinct Causes | JAMA Dermatology | JAMA Network.
Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.
Stevens-Johnson syndrome, named after the two doctors who first described the disease in 1922, is an autoimmune disorder that manifests as a painful rash on the skin, mucous membranes, and genitals. The disease is often caused by an allergic reaction to certain medications.
SJS/TEN is usually caused by a skin reaction to medicine. The symptoms are likely to start showing up one to four weeks after you start taking a new drug. The most common drug triggers of SJS/TEN include antibiotics, epilepsy drugs, sulfa drugs and allopurinol (Aloprim, Zyloprim).
DiagnosisA review of your medical history and a physical exam. Health care providers often can identify Stevens-Johnson syndrome based on your medical history, including a review of your current and recently stopped medications, and a physical exam.Skin biopsy. ... Culture. ... Imaging. ... Blood tests.
Key points about erythema multiforme It's a hypersensitivity reaction to an infection or medicine. Red, raised skin patches appear on the body. These patches often look like “targets.” The most common cause is the herpes simplex virus.
The drugs that most commonly cause Stevens-Johnson syndrome/toxic epidermal necrolysis are: Anticonvulsants: lamotrigine, carbamazepine, phenytoin, phenobarbitone. Allopurinol, especially in doses of more than 100 mg per day. Sulfonamides: cotrimoxazole, sulfasalazine.
Stevens–Johnson syndrome, a form of toxic epidermal necrolysis, is a life-threatening skin condition, in which cell death causes the epidermis to separate from the dermis. The syndrome is thought to be a hypersensitivity complex that affects the skin and the mucous membranes.
The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code L51.1. Click on any term below to browse the alphabetical index.
This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 695.13 was previously used, L51.1 is the appropriate modern ICD10 code.