Hereditary factor VIII deficiency 1 D66 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 2 The 2019 edition of ICD-10-CM D66 became effective on October 1, 2018. 3 This is the American ICD-10-CM version of D66 - other international versions of ICD-10 D66 may differ.
Overactivity. R46.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2018/2019 edition of ICD-10-CM R46.3 became effective on October 1, 2018. This is the American ICD-10-CM version of R46.3 - other international versions of ICD-10 R46.3 may differ.
Hereditary deficiency of other clotting factors. D68.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2019 edition of ICD-10-CM D68.2 became effective on October 1, 2018. This is the American ICD-10-CM version of D68.2 - other international versions of ICD-10 D68.2 may differ.
Hereditary deficiency of other clotting factors. D68.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
D66 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM D66 became effective on October 1, 2021. This is the American ICD-10-CM version of D66 - other international versions of ICD-10 D66 may differ.
ICD-10 code D66 for Hereditary factor VIII deficiency is a medical classification as listed by WHO under the range - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism .
D68. 311 - Acquired hemophilia | ICD-10-CM.
Group 2CodeDescriptionD68.311Acquired hemophilia
Factor VIII levels can be elevated in a number of clinical conditions including carcinoma, leukemia, liver disease, renal disease, hemolytic anemia, diabetes mellitus, deep vein thrombosis, and myocardial infarction.
Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.
Acquired factor VIII deficiency is a bleeding disorder that requires prompt diagnosis and management to avert severe, life-threatening bleeding and death. Despite knowledge of this disorder of coagulation for several decades, relatively little is still known about this disease because of its rare incidence.
D68. 311 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM D68. 311 became effective on October 1, 2021.
Hemophilia B is a hereditary bleeding disorder caused by a lack of blood clotting factor IX. Without enough factor IX, the blood cannot clot properly to control bleeding.
In hemophilia, a blood clotting factor is missing. In Hemophilia A, Factor VIII (8) is missing.
Acquired hemophilia (AH) is a rare autoimmune disorder characterized by bleeding that occurs in patients with no personal or family history of diseases related to clotting/coagulation. Autoimmune disorders occur when the body's immune system mistakenly attacks healthy cells or tissue.
The disease is inherited as an X-linked recessive trait and thus occurs in males and very rarely in homozygous females. Heterozygous females for the disease are known as carriers.
Factor VIII activity is determined utilizing an aPTT-based one-stage clotting time assay . Factor VIII-depleted plasma is used as the substrate and the clotting time with the patient plasma is compared to the clotting time of normal pooled plasma.
Factor VIII is a large glycoprotein cofactor (320 kilodaltons) that is produced mainly in hepatocytes, but also to some extent by liver macrophages, megakaryocytes, and endothelial cells. 6,10 Factor VIII circulates in the plasma bound to von Willebrand factor (vWF) at a concentration of approximately 0.1 mg/mL. 10 The plasma half-life of factor VIII is short at about 8 to 10 hours. 10 Factor VIII deficiency should be suspected when a patient with excessive bleeding has a normal protime (PT) and an extended activated partial thromboplastin time (aPTT).
A lupus anticoagulant may cause factor VIII activity to appear spuriously low and a chromogenic factor VIII activity is recommended in this circumstance.