icd 10 code for hhv 6 encephalitis

What is hhv6 encephalitis?

Human herpesvirus 6 (HHV-6) is a ubiquitous herpesvirus that commonly infects children younger than 3 years. 1. Primary infection sometimes causes exanthema subitum, a common exanthematic disease among infants that may be accompanied by neurologic manifestations such as febrile seizures and encephalitis.

What kind of virus is HHV 6?

Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. HHV-6B infects nearly 100% of human beings, typically before the age of three and often results in fever, diarrhea, sometimes with a rash known as roseola.

What does HHV-6A cause?

Roseola, also called exanthem subitum and sixth disease, is a common, contagious viral infection caused by the human herpesvirus (HHV) 6. This strain of the herpes virus is different than the one that causes cold sores or genital herpes infections. Roseola occurs most often in children aged 6 to 24 months.

Is HHV-6A DNA virus?

HHV-6 is the collective name for the double-stranded DNA viruses HHV-6A and HHV-6B. HHV-6A and HHV-6B, are officially recognized as distinct viruses instead of variants within the herpesvirus family. While much less is known about HHV-6A, it occurs more frequently in the immunocompromised host.

How is HHV-6 diagnosed?

The diagnosis of HHV-6 infection is performed by both serologic and direct methods. The most prominent technique is the quantification of viral DNA in blood, other body fluids, and organs by means of real-time PCR.

Is HSV and HHV the same?

The human herpesvirus or herpes simplex virus (HHV or HSV) is a neurotropic virus that has two distinct serotypes, human herpesvirus 1 and 2 (HHV-1 and HHV-2). Although both viruses are closely related, they contain sufficient differences to enable type identification (Nicoll et al. 2012).

What does it mean if your HHV-6 IGG is high?

Elevated antibody levels may indicate an active infection but results will need to be interpreted by a doctor. An HHV-6 IgM Antibody test can be more accurate at detecting an active or recent infection.

What are HHV-6 IGG antibodies?

A Human Herpesvirus 6 (HHV-6) Antibodies Blood Test is used to aid in the diagnosis of past infection/exposure to roseola infantum; may be useful in diagnosis of chronic fatigue syndrome. Preparation: No special preparation required. Test Results: 3-5 days.

Can adults get HHV-6?

HHV-6 A is less common and may be acquired in adulthood, while the B type generally is acquired in early childhood and is found in the vast majority of the population.

Does everyone have HHV-6?

Although nearly everyone is infected with HHV-6 in childhood, only a small percentage experience reactivation of HHV-6 later in life. Moreover, many of these reactivation events never cause symptoms.

How many herpesviruses are there?

There are eight herpesviruses for which humans are the primary host. They are the herpes simplex virus 1, herpes simplex virus 2, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, Human herpesvirus-6, Human herpesvirus-7, and Kaposi's sarcoma herpes virus.

How do you treat HHV-6 virus?

Antiviral Therapy In immunocompetent patients, no antiviral pharmacologic therapy is recommended. In immunosuppressed hosts with HHV-6 encephalitis, antiviral therapy is recommended. Foscarnet, ganciclovir, and cidofovir are the three antivirals that have in vitro activity against HHV-6.

Is there a cure for HHV-6?

However, no compound has yet been approved exclusively for the treatment of HHV-6. Thus, clinicians most often utilize the anti-cytomegalovirus (CMV) agents ganciclovir (Cytovene® IV), cidofovir (Vistide® IV), and foscarnet (Foscavir® IV) for the clinical treatment of HHV-6 (Table below).

Can HHV-6 Be Cured?

You cannot cure HHV-6, but it does not cause disease in everyone.

Is HHV an STD?

Human herpesvirus 2 (HHV-2): A herpes virus that causes genital herpes, characterized by sores in the area of the genitalia. Genital herpes is a sexually transmitted disease (STD).

Does everyone have HHV-6?

Although nearly everyone is infected with HHV-6 in childhood, only a small percentage experience reactivation of HHV-6 later in life. Moreover, many of these reactivation events never cause symptoms.

MS-DRG Mapping

DRG Group #023-027 - Cranio with major dev impl or acute complex cns pdx with MCC or chemo implant.

ICD-10-CM Alphabetical Index References for 'B10.01 - Human herpesvirus 6 encephalitis'

The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code B10.01. Click on any term below to browse the alphabetical index.

Equivalent ICD-9 Code GENERAL EQUIVALENCE MAPPINGS (GEM)

This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 058.21 was previously used, B10.01 is the appropriate modern ICD10 code.

What is HHV-6?

HHV-6 is the etiological agent of exanthema subitum-associated encephalopathy, which usually occurs in children younger than 3 years. However, primary HHV-6 infection can cause acute encephalopathy without exanthema subitum.

Is HHV 6 a transplant?

HHV-6 encephalitis is a significant consequence of transplant immunosuppression, although it is seen in immun ocompetent patients as well. Interestingly, the characteristics of HHV-6 encephalitis differ between patients who develop the condition through primary infection compared to viral reactivation ( Kawamura 2011 ).

Is HHV-6 a encephalitis?

HHV-6 encephalitis should be considered even among immunocompetent patients presenting with encephalitis and having signs of temporal lobe involvement ( Shahani 2014 ). A NINDS study found HHV-6 DNA in the CSF of 40% of 35 immunocompetent patients with encephalitis of unknown etiology ( Yao 2009 ). HHV-6 encephalitis/encephalopathy associated with primary infection in infants has an unexpectedly poor outcome. In a nationwide survey in Japan, 46.9% of 81 cases resulted in neurological sequelae or death ( Yoshikawa 2009 ). One study found that out of 983 cases of acute encephalopathy in Japan, 17% were caused by HHV-6. 64% of the severe cases with biphasic seizures in this study were attributed to HHV-6, only half of which survived without permanent neurological sequelae ( Hoshino 2012 ).