HPV E6/E7 oncoproteins mediate the development of cervical cancer. Their overexpression, which can be measured as E6/E7 messenger RNA (mRNA) transcripts, is associated with a significantly increased risk of CIN and cervical cancer. 8,9 This test determines the presence of E6/E7 mRNA from 14 high-risk HPV genotypes.
Screening for malignant neoplasm of vagina (Z12. 72) Screening for HPV (V11. 51)
R87. 810 - Cervical high risk human papillomavirus (HPV) DNA test positive | ICD-10-CM.
A study by Yang et al. also showed that a woman tested positive for HPV E6/E7 mRNA had a higher risk of progressing to high grade cervical lesions.
Group 2CodeDescriptionR87.810Cervical high risk human papillomavirus (HPV) DNA test positiveR87.811Vaginal high risk human papillomavirus (HPV) DNA test positive
CPT code 90650 is an FDA-approved HPV vaccine for females only age 9-26. For recipients age 9-18, code 90650 is reimbursed through the VFC program. The three-dose schedule for either code for recipients over age 18 must begin and end before the recipient turns 27.
4 - Encounter for screening for malignant neoplasm of cervix.
ICD-10 code: Z12. 4 Special screening examination for neoplasm of cervix.
Group 1 CPT Codes: G0476. INFECTIOUS AGENT DETECTION BY NUCLEIC ACID (DNA OR RNA); HUMAN PAPILLOMAVIRUS (HPV), HIGH-RISK TYPES (E.G., 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) FOR CERVICAL CANCER SCREENING, MUST BE PERFORMED IN ADDITION TO PAP TEST.
Treatment. There is no medical treatment for HPV infections, but the cervical lesions and warts that can result from HPV infections are treatable.
HPV spreads through sexual contact and is very common in young people — frequently, the test results will be positive. However, HPV infections often clear on their own within a year or two. Cervical changes that lead to cancer usually take several years — often 10 years or more — to develop.
Therapeutics including different forms of vaccines to advanced genome editing techniques, which suppress E6 and E7 activity, have been found to successfully bring down the population of cervical cancer cells infected with HPV.