Lennox-Gastaut syndrome (LGS) is a severe form of epilepsy that typically becomes apparent during infancy or early childhood. Affected children experience several different types of seizures most commonly atonic, tonic and atypical absence seizures.
Causes. Lennox-Gastaut syndrome can have many different causes. The disorder likely has a genetic component, although the specific genetic factors are not well understood. Most cases of Lennox-Gastaut syndrome are caused by an existing neurological abnormality.
LGS, Lennox-Gastaut syndrome....CharacteristicsPrevalence (n=40)From LGS diagnosis to last visit7.8±4.2Organ involvementNeuromuscular system40 (100)Gastrointestinal system10 (25)45 more rows•Jan 1, 2019
Lennox-Gastaut syndrome can be caused by a variety of conditions, including brain malformations, tuberous sclerosis, perinatal asphyxia, severe head injury, central nervous system infection, and inherited genetic and inherited degenerative or metabolic conditions.
Generalized 3 Hz spike and wave discharges in a child with childhood absence epilepsy. LGS was named for neurologists William G. Lennox (Boston, USA) and Henri Gastaut (Marseille, France), who independently described the condition. The international LGS Awareness Day is on November 1.
Their mean age was 23.0 ± 3.8 years (range 18.7–35.8 years) and the mean follow-up duration was 19.3 ± 6.0 years (range 8.3–32.5 years)....Clinical profiles.CharacteristicsValues>60 months, n (%)21 (30.9)Brain MRI, n (%)Normal22 (32.4)Atrophy only11 (16.2)14 more rows
Tonic-clonic seizures, previously known as grand mal seizures, are the most dramatic type of epileptic seizure. They can cause an abrupt loss of consciousness and body stiffening, twitching and shaking. They sometimes cause loss of bladder control or biting your tongue.
Lennox-Gastaut syndrome is a progressive epilepsy syndrome that causes tonic and atypical absence seizures and intellectual disability. It is difficult to treat, although some newer treatments are being investigated.