icd 10 code for light chain deposition disease

What is light chain deposition disease (LCD)?

Light chain deposition disease. Light chain deposition disease ( LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins, called light chains (LCs), in the body. LCs are normally cleared by the kidneys, but in LCDD, these light chain deposits damage organs and cause disease.

What is the ICD 10 code for light chain amyloidosis?

Light chain (AL) amyloidosis 1 E85.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 2 The 2021 edition of ICD-10-CM E85.81 became effective on October 1, 2020. 3 This is the American ICD-10-CM version of E85.81 - other international versions of ICD-10 E85.81 may differ. More ...

What is the ICD 10 code for heavy chain disease?

Heavy chain disease 2016 2017 2018 2019 2020 2021 Billable/Specific Code C88.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2021 edition of ICD-10-CM C88.2 became effective on October 1, 2020.

How do you code manifestation and underlying condition in ICD 10 cm?

For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code.

What is light chain deposition disease?

Overview. Light chain deposition disease (LCDD) is a rare condition characterized by the deposition of specific proteins (monoclonal light chains) in the kidneys and other organs. Light chains are used to make antibodies that the body needs to fight infection.

What is the ICD-10 code for light chain disease?

ICD-10 code E85. 81 for Light chain (AL) amyloidosis is a medical classification as listed by WHO under the range - Endocrine, nutritional and metabolic diseases .

What is the ICD-10 code for light chain nephropathy?

The 2022 edition of ICD-10-CM N05. 6 became effective on October 1, 2021. This is the American ICD-10-CM version of N05.

How is light chain deposition disease diagnosed?

Diagnosis of light-chain deposition disease (LCDD) LCDD is often found when a person is evaluated for proteinuria or nephrotic syndrome and a renal biopsy is performed. The tiny piece of removed kidney tissue is examined under an electron microscope and light chains deposited in the kidney can be seen.

What is the ICD-10 code for kappa light chain disease?

E85. 81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

What is light chain nephropathy?

Light chain cast nephropathy (LCCN) is the most common renal disease caused by multiple myeloma (MM). In addition to ordinary light chain protein casts, there are a few rare casts with unique shapes, including light chain amyloid casts (LCAC) and light chain crystal casts (LCCC).

What is the ICD-10 code for nephropathy?

Nephropathy induced by unspecified drug, medicament or biological substance. N14. 2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM N14.

What is light chain amyloidosis?

Amyloid light chain amyloidosis is a "protein misfolding disorder." It causes organs and tissues, including the heart, kidney, skin, stomach, small and large intestines, nerves and liver, to thicken and eventually lose function. Medications destroy plasma cells that make the light chain proteins.

What is kappa and lambda light chain?

Light chains are proteins produced by immune cells called plasma cells. Also called kappa and lambda light chains, they link together with other proteins (heavy chains) to form immunoglobulins (also known as antibodies) that target and neutralize specific threats to the body such as bacteria and viruses.

What is light chain myeloma?

Abstract. Light-chain multiple myeloma (LCMM) is a less frequent type of multiple myeloma (MM), with a more aggressive course and poorer prognosis. It is characterized by the inability of the malignant plasma cells to produce heavy chains, resulting in the exclusive production of light chains.

Is Kappa a light chain disease?

Light chain myeloma can be classified as lambda or kappa light chain myeloma, depending on which type the cancerous cells produce. These light chains can build up in the kidneys, nerves, or other organs and cause serious complications.

What is light chain disease symptoms?

What are the symptoms? The symptoms a person has vary based on the reason for the light chain production. Symptoms can be related to the disease as it affects your body as a whole, such as weakness and fatigue, weight loss, bone pain, or numbness/tingling of your arms or legs.

What is the code for a primary malignant neoplasm?

A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere.

What is mu heavy chain disease?

Most patients present with slowly progressive chronic lymphocytic leukemia (cll). In contrast to most cases of cll, mu heavy chain disease is associated with hepatosplenomegaly and absence of lymphadenopathy. A clonal disorder characterized by the secretion of a truncated gamma chain.

What is a heavy chain in immunoglobulin?

Heavy chains are immunologically related to the fc fragment of the immunoglobulin chain.

What is a light chain deposition disease?

Light chain deposition disease ( LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins, called light chains (LCs), in the body. LCs are normally cleared by the kidneys, but in LCDD, these light chain deposits damage organs ...

What happens if you have light chain deposition?

About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's macroglobulinemia, and the monoclonal gammopathy of undetermined significance premalignant stages ...

Where are light chains deposited in LCDD?

Unlike in AL amyloidosis, in which light chains are laid down in characteristic amyloid deposits, in LCDD, light chains are deposited in non-amyloid granules.

Definition

The monoclonal immunoglobulin (Ig) deposition diseases are closely related disorder s characterized by visceral and soft tissue deposition of aberrant Ig, resulting in compromised organ function.

Sources

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.