Ulcers and NSAIDs. Peptic ulcer disease is a well-recognised complication of NSAID use. Inhibition of COX-1 in the gastrointestinal tract leads to a reduction of prostaglandin secretion and its cytoprotective effects in gastric mucosa. This therefore increases the susceptibility to mucosal injury.
Approximately 15% of patients on long-term treatment with NSAIDs develop a peptic ulcer (ulceration of the stomach or duodenum).
NSAIDs can cause ulcers by interfering with the stomach's ability to protect itself from gastric acids. 2 While these acids are vital to the digestive process, they can cause damage if the protective barriers of the stomach are compromised.
ICD-10-CM Code for Long term (current) use of non-steroidal anti-inflammatories (NSAID) Z79. 1.
NSAIDs may be associated with many gastrointestinal problems, ranging from mild to severe dyspeptic symptoms, the development of gastric or duodenal ulceration, haemorrhage or perforation, and other events which may lead to hospitalisation or death.
When taken for a long time, painkillers like diclofenac and ibuprofen can lead to ulcers in the stomach and duodenum. But the risk of this happening can be clearly reduced by also taking medication to protect your stomach.
Histamine (H2) antagonists, omeprazole, sucralfate and E-prostaglandin (PGE) analogs are effective for the treatment of NSAID-induced gastric and duodenal ulcers, if NSAIDs are discontinued.
Misoprostol, PPIs, and double dose H2RAs are effective at preventing chronic NSAID related endoscopic gastric and duodenal ulcers. Lower doses of misoprostol are less effective and are still associated with diarrhoea.
When NSAIDs irritate the gastric mucosa, they weaken the resistance to acid, causing gastritis, ulcers, bleeding, or perforation. The damage ranges from superficial injury to single or multiple ulcers, some of which may bleed.
ICD-10 Codes for Long-term TherapiesCodeLong-term (current) use ofZ79.899other drug therapyH – Not Valid for Claim SubmissionZ79drug therapy21 more rows•Aug 15, 2017
ICD-10 code Z79. 899 for Other long term (current) drug therapy is a medical classification as listed by WHO under the range - Factors influencing health status and contact with health services .
The main types of NSAIDs include: ibuprofen. naproxen. diclofenac.