B96.21
What is Shiga toxin bacteria?
Definition. Shiga toxin-producing Escherichia coli (STEC) are bacteria that can cause bloody diarrhea in infected people. In rare cases, the same bacterium can also cause a kidney disease known as Hemolytic Uremic Syndrome. The most well known member of this group of bacteria is E. coli O157:H7.
Is Shiga toxin the same as E. coli?
Some kinds of E. coli cause disease by making a toxin called Shiga toxin. The bacteria that make these toxins are called “Shiga toxin-producing” E. coli, or STEC for short.
Why is it called Shiga toxin?
The toxins are named after Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae. Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli. The most common sources for Shiga toxin are the bacteria S.
What kind of toxin is a Shiga toxin?
The Stxs (also known as Vero toxins, and previously as Shiga-like toxins) are a group of bacterial AB5 protein toxins of about 70 kDa that inhibit protein synthesis in sensitive eukaryotic cells. Protein synthesis is blocked by the Stxs through the removal of an adenine residue from the 28S rRNA of the 60S ribosome.Dec 18, 2014
Is Shiga toxin endotoxin or exotoxin?
protein exotoxin
Shiga toxin (Stx) is a protein exotoxin expressed by the Gram-negative bacteria Shigella dysenteriae serotype 1.
Is Shiga toxin the same as Shigella?
[Katherine Lamba] Well, Shiga toxins are a group of toxins that can cause human cell damage and cell death. They're typically produced by two types of bacteria, known as Shiga toxin- producing E. coli and a specific type of Shigella known as Shigella dysenteriae serotype 1.Apr 3, 2016
What is a Shiga toxin test?
These tests are used to detect the presence of Escherichia coli (E. coli) that produce Shiga toxin and to help diagnose an infection of the digestive tract due to these bacteria. E. coli bacteria are part of healthy digestive systems in humans and other mammals, but there are strains of E.Jan 14, 2020
Where do you get Shiga toxin?
Infection most typically occurs by eating contaminated food, particularly raw or undercooked meat. Infection can also occur after eating of any product contaminated with STEC, including lettuce, alfalfa sprouts, salami, and raw (unpasteurized) milk, juice, or cider. Infected people can spread E.
How does Shiga toxin cause HUS?
These strains are called Shiga toxin-producing E. coli, or STEC. When you are infected with a strain of STEC , the Shiga toxin can enter your bloodstream and cause damage to your blood vessels, which may lead to HUS .Jul 22, 2021
Is Shiga toxin an AB toxin?
These are secreted bacterial proteins that enter cells and exert their toxic effects by affecting intracellular processes. Other AB toxins include tetanus, cholera, anthrax, shiga and diphtheria toxins. They are called AB toxins because they have two component parts.
Is Shiga toxin an endotoxin?
Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro. Infect Immun. 1992 Apr;60(4):1536-43.
What is Shiga toxin genes PCR?
PCR detection of stx, the gene encoding Shiga toxin, directly from fecal specimens is a sensitive and specific technique, providing same-day results. PCR assay identifies non-O157:H7 Shiga toxin-producing bacteria, extending the utility beyond strains identifiable on SMAC agar.
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