Medications most likely to cause Stevens-Johnson syndrome include:
Stevens-Johnson syndrome may cause rare but potentially severe respiratory complications. Bronchiolitis obliterans secondary to Stevens-Johnson syndrome may present with delayed onset and prolonged worsening of respiratory distress.
Stevens-Johnson syndrome can happen to anyone, both males and females, though there are certain people who are more at risk, including: A personal or family history of Stevens-Johnson syndrome; People who have the HLA-B*1502 gene, which is more common among certain ethnic groups such as those of Chinese, Indian, or Southeast Asian heritage
Mortality can be as high as 7.5% in children and 20 to 25% in adults but tends to be lower with early treatment. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are clinically similar except for their distribution.
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are now believed to be variants of the same condition, distinct from erythema multiforme. SJS/TEN is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss.
Erythema Multiforme With Mucous Membrane Involvement and Stevens-Johnson Syndrome Are Clinically Different Disorders With Distinct Causes | JAMA Dermatology | JAMA Network.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of the same disease. They are the more severe drug eruptions, with a mortality around 30% for TEN. The confusion between erythema multiforme major and SJS means that erythema multiforme major is the main differential diagnosis.
Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.
Acute Generalized Exanthematous Pustulosis (AGEP) is an uncommon yet severe skin reaction that is often confused with SJS/TEN. It is a drug reaction presenting with non-follicular, sterile pustules on an erythematous and edematous base.
Stevens-Johnson syndrome, named after the two doctors who first described the disease in 1922, is an autoimmune disorder that manifests as a painful rash on the skin, mucous membranes, and genitals. The disease is often caused by an allergic reaction to certain medications.
Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.
Antibiotics are the most common cause of Stevens-Johnson syndrome, followed by analgesics, cough and cold medication, NSAIDs, psycho-epileptics, and antigout drugs. Of antibiotics, penicillins and sulfa drugs are prominent culprits; ciprofloxacin has also been reported.
Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction—often antibiotics or anticonvulsives.
Even before histopathologic results are available, dermatologists can help take some of the panic out of the room when Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) is first on the differential diagnosis for the referring physician, she said.
Symptoms of Stevens-Johnson syndrome Credit: The rash usually starts on the upper body before quickly spreading to the face, arms, legs and other areas of the body, such as the genitals. It's not usually itchy. Blisters then appear on your skin, which burst to leave painful sores.
Stevens-Johnson syndrome ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic illness, toxic epidermal necrolysis (TEN).
Toxic epidermolysis necrosis on a woman's back TEN causes large areas of blistering, peeling skin. Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction, usually caused by a medication. It's a severe form of Stevens-Johnson syndrome (SJS).
Stevens–Johnson syndrome, a form of toxic epidermal necrolysis, is a life-threatening skin condition, in which cell death causes the epidermis to separate from the dermis. The syndrome is thought to be a hypersensitivity complex that affects the skin and the mucous membranes.
The ICD-10-CM Alphabetical Index links the below-listed medical terms to the ICD code L51.1. Click on any term below to browse the alphabetical index.
This is the official exact match mapping between ICD9 and ICD10, as provided by the General Equivalency mapping crosswalk. This means that in all cases where the ICD9 code 695.13 was previously used, L51.1 is the appropriate modern ICD10 code.