Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells.
For additional information about WM, please see the free Leukemia & Lymphoma Society (LLS) booklet Non-Hodgkin Lymphoma. Waldenström macroglobulinemia (WM), also called “lymphoplasmacytic lymphoma,” is a rare, indolent (slow-growing) blood cancer that is treatable with available therapies but is not curable.
Waldenström macroglobulinemia (WM), which is a subtype of lymphoplasmacytic lymphoma, is a rare indolent (slow-growing) B-cell lymphoma that occurs in less than two percent of patients with non-Hodgkin lymphoma (NHL). There are about 5,000 new cases of WM diagnosed each year in the United States.
Symptoms can include heart palpitations, feeling tired and weak, cough, shortness of breath, rapid weight gain, and swelling in the feet and legs. Infections: The high levels of abnormal antibody in WM can slow the body's normal antibody production. This makes it harder for the body to fight infections.
Waldenström macroglobulinemia represents a lymphoplasmacytic lymphoma with an indolent clinical course. The existing literature associates this hematologic malignancy with various autoimmune disorders. Notwithstanding, these autoimmune conditions have not been comprehensively characterized or systematized to date.
The International Waldenstrom's Macroglobulinemia Foundation has found that improved treatments have put median survival rates between 14 and 16 years. Median survival is defined as the length of time at which 50 percent of people with the disease have died while the rest are still living.
Lymphoplasmacytic lymphoma, also known as Waldenstrom macroglobulinemia, is a low-grade B cell lymphoproliferative neoplasm characterized by small lymphocytes and monoclonal IgM monoclonal gammopathy. The disorder presents with symptoms related to bone marrow infiltration and IgM monoclonal gammopathy.
Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone within the bone marrow. While the cause of myeloma is not known, interleukin 6 may play a role in driving myeloma cell proliferation. Waldenstrom's macroglobulinemia (WM) is a proliferative disease of B-lymphocytes.
The most common type of biopsy for Waldenstrom macroglobulinemia is either a bone marrow biopsy or a biopsy of the lymph nodes in the neck, under the arms, or in the groin. A biopsy may also be taken from the chest or abdomen while using a computed tomography (CT or CAT) scan to guide the doctor.
What causes Waldenstrom macroglobulinemia (WM)? Doctors do not know what causes WM but believe it involves a gene mutation. Recent research has found that WM cells have a mutation (change) in a gene known as MYD88, which normally helps immune system cells signal each other and helps keep them alive.
Waldenstrom macroglobulinemia (WM) is a type of non-Hodgkin lymphoma (NHL). The cancer cells make large amounts of an abnormal protein (called a macroglobulin). Another name for WM is lymphoplasmacytic lymphoma.
The 2 main ways to treat WM are chemotherapy and different types of biological therapy (immunotherapy). One or both of these types of treatments might be used.
C88.0 is a billable ICD code used to specify a diagnosis of waldenstrom macroglobulinemia. A 'billable code' is detailed enough to be used to specify a medical diagnosis.
This means that while there is no exact mapping between this ICD10 code C88.0 and a single ICD9 code, 273.3 is an approximate match for comparison and conversion purposes.
The main attributing antibody is immunoglobulin M (IgM). WM is an "indolent lymphoma," (i.e., one that tends to grow and spread slowly). It is a type of lymphoproliferative disease, which shares clinical characteristics with the indolent non-Hodgkin lymphomas. Specialty: Hematology And Oncology. MeSH Code:
DRG Group #820-822 - Lymphoma and leukemia with major operating room procedure with CC.
The 2022 edition of ICD-10-CM D89.2 became effective on October 1, 2021.
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Waldenstrom Macroglobulinemia (WM) is a subset of lymph oplasmacytic lymphoma. Patients with WM have IgM ( immunoglobulin M) in their blood and/or bone marrow. IgM is also called IgM monoclonal gammopathy. There will also be an increased number of lymphocyte s in the blood.
Waldenstrom macroglobulinemia (WM) is found in a substantial subset of patients with LPL, but is not synonymous with it; it is defined as LPL with bone marrow involvement and an IgM monoclonal gammopathy of any concentration.