52959-539 NDC - CELEBREX () Drug Information Labeler Information Package Information NDC Record Download Record Home > NDC Lookup > NDC: 52959-539 Drug Information
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What kind of drug is Celebrex 100mg?
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What is a contraindication for Celebrex?
Feb 14, 2022 · National Drug Code 52959-539 is assigned to celebrex with active ingredient(s) and is labeled by H.J. Harkins Company, Inc.
What is the recommended dose of Celebrex for hepatic impairment?
ICD 9 Codes. A federal government website managed and paid for by the U.S. Centers for Medicare & Medicaid Services. 7500 Security Boulevard, Baltimore, MD 21244.
Can Celebrex cause thrombotic events?
Oct 01, 2021 · Z79.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Short description: Long term (current) use of non-steroidal non-inflam (NSAID) The 2022 edition of ICD-10-CM Z79.1 became effective on October 1, 2021.
What is the ICD-10 code for NSAID use?
Z79.1Long term (current) use of non-steroidal anti-inflammatories (NSAID) Z79. 1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
What is Celebrex used for?
Celecoxib is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine).
What drug class is celecoxib?
Celebrex belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
What is the ICD 9 code for arthritis?
ICD-9-CM 714.0 converts approximately to: 2022 ICD-10-CM M06. 9 Rheumatoid arthritis, unspecified.
What is another name for Celebrex?
What is Celebrex? Celebrex is the brand name for celecoxib, an NSAID that treats arthritis. It can also treat arthritis of the spine as well as menstrual cramps. Celebrex is taken once or twice daily.Dec 10, 2019
What is the difference between Celebrex and meloxicam?
Celebrex (celecoxib) Mobic (meloxicam) works well for pain and inflammation and you only take it once a day, but you need a prescription. Relieves pain and inflammation. Celebrex (celecoxib) works well for treating pain, but is not a good option if you have heart problems.
Is celecoxib same as Celebrex?
Celecoxib is commonly known by the brand name Celebrex®. Celecoxib (Sell-e-COX-eb) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.
Is Celebrex a corticosteroid?
Common corticosteroids include prednisone, cortisone, and methylprednisolone. Examples of NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), oxaprozin (Daypro), and piroxicam (Feldene).
How do you pronounce the generic for Celebrex?
0:000:19How to pronounce Celecoxib (Celebrex) (Memorizing ... - YouTubeYouTubeStart of suggested clipEnd of suggested clipAnd said celecoxib.MoreAnd said celecoxib.
What is the ICD-10 code for inflammatory arthritis?
M06.4M06. 4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM M06.
What is the ICD-10 code for joint pain?
Code M25. 50 is the diagnosis code used for Pain in the Unspecified Joint. It falls under the category of Diseases of the musculoskeletal system and connective tissue.
What is the ICD-10 code for osteoarthritis?
M19.90ICD-10 code M19. 90 for Unspecified osteoarthritis, unspecified site is a medical classification as listed by WHO under the range - Arthropathies .
What is the color of Celebrex?
Celebrex (celecoxib) 50 mg capsules are white, with reverse printed white on red band of body and cap with markings of 7767 on the cap and 50 on the body, supplied as:
What is the metabolite of celecoxib?
Three metabolites, a primary alcohol, the corresponding carboxylic acid and its glucuronide conjugate, have been identified in human plasma. These metabolites are inactive as COX-1 or COX-2 inhibitors.
How long does celecoxib stay in your system?
It has extensive distribution and high protein binding. It is primarily metabolized by CYP2C9 with a half-life of approximately 11 hours.
How long does it take for celecoxib to peak?
Peak plasma levels of celecoxib occur approximately 3 hours after an oral dose. Under fasting conditions, both peak plasma levels (C max) and area under the curve (AUC) are roughly dose-proportional up to 200 mg twice daily; at higher doses there are less than proportional increases in C max and AUC ( see Food Effects ). Absolute bioavailability studies have not been conducted. With multiple dosing, steady-state conditions are reached on or before Day 5. The pharmacokinetic parameters of celecoxib in a group of healthy subjects are shown in Table 4.
Can Celebrex cause oligohydramnios?
Use of NSAIDs, including Celebrex, at about 20 weeks gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. Oligohydramnios is often, but not always, reversible with treatment discontinuation. Complications of prolonged oligohydramnios may, for example, include limb contractures and delayed lung maturation. In some postmarketing cases of impaired neonatal renal function, invasive procedures such as exchange transfusion or dialysis were required.
Does Celebrex cause ovarian follicle rupture?
Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including Celebrex, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin mediated follicular rupture required for ovulation. Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation. Consider withdrawal of NSAIDs, including Celebrex, in women who have difficulties conceiving or who are undergoing investigation of infertility.
Does Celebrex help with pain?
Single doses [ see Dosage and Administration (2.6)] of Celebrex provided pain relief within 60 minutes.
Dosage and Administration
- General Dosing Instructions
Carefully consider the potential benefits and risks of Celebrex and other treatment options before deciding to use Celebrex. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5)]. These doses can be … - Osteoarthritis
For OA, the dosage is 200 mg per day administered as a single dose or as 100 mg twice daily.
Dosage Forms and Strengths
- Celebrex (celecoxib) capsules: 50 mg white, with reverse printed white on red band of body and cap with markings of 7767 on the cap and 50 on the body. 100 mg white, with reverse printed white on blue band of body and cap with markings of 7767 on the cap and 100 on the body. 200 mg white, with reverse printed white on gold band with markings of 7767 on the cap and 200 on …
Contraindications
- Celebrex is contraindicated in the following patients: 1. Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to celecoxib, any components of the drug product [see Warnings and Precautions (5.7, 5.9)]. 2. History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions t…
Warnings and Precautions
- Cardiovascular Thrombotic Events
Clinical trials of several cyclooxygenase-2 (COX-2) selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, including myocardial infarction (MI) and stroke, which can be fatal. Based on available d… - Gastrointestinal Bleeding, Ulceration, and Perforation
NSAIDs, including celecoxib cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or …
Adverse Reactions
- The following adverse reactions are discussed in greater detail in other sections of the labeling: 1. Cardiovascular Thrombotic Events [see Warnings and Precautions (5.1)] 2. GI Bleeding, Ulceration and Perforation [see Warnings and Precautions (5.2)] 3. Hepatotoxicity [see Warnings and Precautions (5.3)] 4. Hypertension [see Warnings and Precautions (5.4)] 5. Heart Failure and Ede…
Use in Specific Populations
- Pregnancy
Pregnancy Category C. Pregnancy category D from 30 weeks of gestation onward. Risk Summary Use of NSAIDs, including Celebrex, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Avoid use of NSAIDs, including Celebrex, in pre… - Lactation
Risk Summary Limited data from 3 published reports that included a total of 12 breastfeeding women showed low levels of Celebrex in breast milk. The calculated average daily infant dose was 10 to 40 mcg/kg/day, less than 1% of the weight-based therapeutic dose for a two-year old-…
Overdosage
- Symptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. Gastrointestinal bleeding has occurred. Hypertension, acute renal failure, respiratory depression, and coma have occurred, but were rare [see Warnings and Precautions (…
Description
- Celebrex (celecoxib) capsule is a nonsteroidal anti-inflammatory drug, available as capsules containing 50 mg, 100 mg, 200 mg and 400 mg celecoxib for oral administration. The chemical name is 4-[5-(4-methylphenyl)- 3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide and is a diaryl-substituted pyrazole. The molecular weight is 381.38. Its molecular formula is C17H14F3…
Clinical Pharmacology
- Mechanism of Action
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of Celebrex is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentratio… - Pharmacodynamics
Platelets In clinical trials using normal volunteers, Celebrex at single doses up to 800 mg and multiple doses of 600 mg twice daily for up to 7 days duration (higher than recommended therapeutic doses) had no effect on reduction of platelet aggregation or increase in bleeding tim…
Nonclinical Toxicology
- Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenesis Celecoxib was not carcinogenic in Sprague-Dawley rats given oral doses up to 200 mg/kg for males and 10 mg/kg for females (approximately 2-to 4-times the human exposure as measured by the AUC0–24 at 200 mg twice daily) or in mice given oral doses up to 25 mg/kg … - Animal Toxicology
An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile rat. These reproductive findings while apparently treatment-rela…
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