2014 ICD-9-CM Diagnosis Code 288.2 : Genetic anomalies of leukocytes. Free, official information about 2014 (and also 2015) ICD-9-CM diagnosis code 288.2, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
Short description: Genetic anomaly leukocyt. ICD-9-CM 288.2 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 288.2 should only be used for claims with a date of service on or before September 30, 2015.
Oct 15, 2021 · Leukocyte adhesion deficiency (LAD) is a defect of cellular adhesion molecules resulting in clinical syndromes. It is a combined (B cell) and cellular (T cell) immunodeficiency disorder. ... Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. A case report and ...
Leukocyte adhesion deficiency (LAD) is a primary immunodeficiency that causes individuals to be abnormally susceptible to developing frequent soft-tissue infections, gum inflammation, and tooth loss. The white blood cells, or leukocytes, lack a protein on their surface that makes them unable to enter infection sites and kill bacteria and other foreign invaders.
Leukocyte adhesion deficiency (LAD) is a primary immunodeficiency that causes individuals to be abnormally susceptible to developing frequent soft-tissue infections, gum inflammation, and tooth loss. The white blood cells, or leukocytes, lack a protein on their surface ...
Leukocyte adhesion deficiency type I (LAD1): Starting from birth, infants with LAD1 develop serious bacterial infections and inflammation. One of the first signs is the delayed detachment of the umbilical cord stump, which usually falls off within the first 2 weeks of life; in infants with LAD1, this separation can occur at 3 weeks or later.
A hallmark of LAD1 is the lack of pus formation at sites of infection. Wounds are slow to heal, which can lead to additional infection. Because of repeat infections, life expectancy of individuals with LAD1 is often severely shortened. LAD1 is caused by defects in the ITGB2 gene, which makes the molecule CD18.
Pneumonia, chronic middle ear infections (otitis media), periodontitis, and localized infections of the skin (cellulitis) are common. No pus formation is seen at the site of infection.
A CBC can detect elevated levels of neutrophils and lymphocytes. A diagnosis of LAD1 should be considered in any infant with recurrent soft tissue infections and a high white cell count. A diagnosis of any of the 3 forms of LAD can be confirmed through molecular genetic testing.
Leukocyte Adhesion Deficiency (LAD) Evaluation (CD15s,CD18), FC - LAD is an autosomal recessive immunodeficiency disorder associated with recurrent bacterial and fungal infections. Two forms of LAD have been described.
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