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G72. 0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM G72.
A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed to certain drugs.
As the name suggests, statin intolerance occurs when a patient is unable to continue to use a statin, either because of the development of a side effect or because of evidence on a blood test that certain markers of liver function or muscle function (creatine kinase) are sufficiently abnormal to cause concern. 2.
Side effects can vary between different statins, but common side effects include:headache.dizziness.feeling sick.feeling unusually tired or physically weak.digestive system problems, such as constipation, diarrhoea, indigestion or farting.muscle pain.sleep problems.low blood platelet count.
The most severe adverse effect of statins is myotoxicity, in the form of myopathy, myalgia, myositis or rhabdomyolysis. Clinical trials commonly define statin toxicity as myalgia or muscle weakness with creatine kinase (CK) levels greater than 10 times the normal upper limit.
Symptoms of statin induced myopathy include fatigue, muscle pain, muscle tenderness, muscle weakness, nocturnal cramping, and tendon pain. The muscle symptoms tend to be proximal, generalised, and worse with exercise.
6X5- when a patient has know intolerance to statin medication.
Myalgia was defined as muscle discomfort including aches, soreness, stiffness, tenderness, or cramps with a normal CPK level. Myopathy was defined as muscle weakness, with or without CPK elevation.
Statin intolerance has been effectively managed either by the use of alternate-day statin regimen with longer half lives like atorvastatin and rosuvastatin, combination of statins with non-statins, dietary interventions, or by specific pharmacotherapies.
Fluvastatin was associated with the lowest risk of muscular symptoms (OR 0.33, 95% CI: 0.26 to 0.42). Most recently, Naci et al conducted a meta-analysis evaluating the comparative tolerability of statins.
In one study, daily supplementation with a combination of antioxidants (800 IU of vitamin E, 1,000 mg of vitamin C, 25 mg of beta-carotene, and 100 mcg of selenium) blocked the beneficial effect of simvastatin-plus-niacin on HDL cholesterol levels.
Researchers have linked a particularly severe form of myopathy called rhabdomyolysis to the use of statins. With this potentially life-threatening complication, muscle tissue dies and products of the damaged cells can enter the bloodstream. Some of these products are toxic to the kidneys and may lead to kidney failure.