Oct 01, 2021 · The 2022 edition of ICD-10-CM M31.1 became effective on October 1, 2021. This is the American ICD-10-CM version of M31.1 - other international versions of ICD-10 M31.1 may differ. A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities ...
Thrombotic microangiopathy Short description: Thrombot microangiopathy. ICD-9-CM 446.6 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 446.6 should only be used for claims with a date of …
446.7. ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 446.6 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services.
The following ICD10 Codes match 'Thrombotic Thrombocytopenic Purpura'. Quickly lookup the latest ICD-10 CM medical diagnosis codes or browse a complete list sorted by chapter or section. Search Search Browse. Chapter Overview. A00-B99. C00-D49. D50-D89. E00-E89. F01-F99. G00-G99. H00-H59. H60-H95.
TTP is characterized by thrombotic microangiopathy (TMA), the formation of blood clots in small blood vessels throughout the body , which can lead to microangiopathic hemolytic anemia and thrombocytopenia. This characteristic is shared by two related syndromes, hemolytic-uremic syndrome (HUS) and atypical hemolytic uremic syndrome (aHUS). Consequently, differential diagnosis of these TMA-causing diseases is essential. In addition to TMA, one or more of the following symptoms may be present in each of these diseases: neurological symptoms (e.g. confusion, cerebral convulsions seizures, ); kidney impairment (e.g. elevated creatinine, decreased estimated glomerular filtration rate [eGFR], abnormal urinalysis ); and gastrointestinal (GI) symptoms (e.g. diarrhea nausea/vomiting, abdominal pain, gastroenteritis. Unlike HUS and aHUS, TTP is known to be caused by an acquired defect in the ADAMTS13 protein, so a lab test showing ≤5% of normal ADAMTS13 levels is indicative of TTP. ADAMTS13 levels above 5%, coupled with a positive test for shiga-toxin/enterohemorrhagic E. coli (EHEC), are more likely indicative of HUS, whereas absence of shiga-toxin/EHEC can confirm a diagnosis of aHUS.
Thrombotic thrombocytopenic purpura ( TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. Symptoms may include large bruises, fever, weakness, shortness of breath, ...
TTP of unknown cause was long known as idiopathic TTP but in 1998 the majority of cases were shown to be caused by the inhibition of the enzyme ADAMTS13 by antibodies. The relationship of reduced ADAMTS13 to the pathogenesis of TTP is known as the Furlan-Tsai hypothesis, after the two independent groups of researchers who published their research in the same issue of the New England Journal of Medicine. These cases are now classed as an autoimmune disease and are known as autoimmune TTP (not to be confused with immune/idiopathic thrombocytopenic purpura ).
ADAMTS13 is a metalloproteinase responsible for the breakdown of von Willebrand factor (vWF), a protein that links platelets, blood clots, and the blood vessel wall in the process of blood coagulation. Very large vWF multimers are more prone to lead to coagulation.
The signs and symptoms of TTP may at first be subtle and nonspecific. Many people experience an influenza-like or diarrheal illness before developing TTP. Neurological symptoms are very common and vary greatly in severity. Frequently reported symptoms include feeling very tired, confusion, and headaches. Seizures and symptoms similar to those of a stroke can also be seen. Other symptoms include, but are not limited to jaundice or paleness of the skin, a fast heart rate or shortness of breath, or pinpoint-sized purple or reddish dots on the skin known as petechiae.
Secondary TTP is diagnosed when the person's history mentions one of the known features associated with TTP. It comprises about 40% of all cases of TTP. Predisposing factors are: 1 Cancer 2 Bone marrow transplantation 3 Pregnancy 4 Medication use:#N#Antiviral drugs ( acyclovir)#N#Certain chemotherapy medications such as gemcitabine and mitomycin C#N#Quinine#N#Oxymorphone#N#Quetiapine#N#Bevacizumab#N#Sunitinib#N#Platelet aggregation inhibitors ( ticlopidine, clopidogrel, and prasugrel)#N#Immunosuppressants ( ciclosporin, mitomycin, tacrolimus /FK506, interferon-α)#N#Hormone altering drugs (estrogens, contraceptives, hormone replacement therapy) 5 HIV-1 infection
TTP was initially described by Eli Moschcowitz at the Beth Israel Hospital in New York City in 1925. Moschcowitz ascribed the disease (incorrectly, as now known) to a toxic cause. Moschcowitz noted his patient, a 16-year-old girl, had anemia, small and large bruises, microscopic hematuria, and, at autopsy, disseminated microvascular thrombi. In 1966, a review of 16 new cases and 255 previously reported cases led to the formulation of the classical pentad of symptoms and findings (i.e., thrombocytopenia, microangiopathic hemolytic anemia, neurological symptoms, kidney failure, fever); in this series, mortality rates were found to be very high (90%).
287.1 is a legacy non-billable code used to specify a medical diagnosis of qualitative platelet defects.
Type 1 Excludes Notes - A type 1 Excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
NOS "Not otherwise specified" - This abbreviation is the equivalent of unspecified.
When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate. Includes Notes - This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
NEC "Not elsewhere classifiable" - This abbreviation in the Alphabetic Index represents "other specified". When a specific code is not available for a condition, the Alphabetic Index directs the coder to the "other specified” code in the Tabular List.