Cytomegalovirus (CMV) is a virus found around the world. It is related to the viruses that cause chickenpox and infectious mononucleosis (mono). Between 50% and 80% of adults in the United States have had a CMV infection by age 40. Once CMV is in a person's body, it stays there for life.
The standard laboratory test for diagnosing congenital CMV infection is polymerase chain reaction (PCR) on saliva, with urine usually collected and tested for confirmation. The reason for the confirmatory test on urine is that most CMV seropositive mothers shed CMV in their breast milk.
CMV is mainly spread through close contact with someone who already has CMV. It can be passed on through sexual contact and contact with other body fluids including saliva, blood, breast milk, tears, pee and poo. CMV can only be passed on when it's "active".
Also known as HCMV, CMV, or human herpesvirus 5 (HHV-5), cytomegalovirus is the most commonly transmitted virus to a developing fetus. The Centers for Disease Control and Prevention (CDC) estimate that over 50% of adults in the United States have contracted the virus by 40 years old.
Human cytomegalovirus is a common herpesvirus that is linked to autoimmunity, especially in genetically predisposed persons.
If you have symptoms of primary CMV, they're mild and include: Fatigue. Swollen glands. Fever....Babies born with CMV might have:Premature delivery.Small size or low birth weight.Bruise-like rashes.Yellow skin or eyes (jaundice)Swollen liver and spleen.Small head (microcephaly)Seizures.Hearing loss.More items...•
Although the virus is not highly communicable, it can be spread from person to person by direct contact. The virus is shed in the urine, saliva, semen and to a lesser extent in other body fluids. Transmission can also occur from an infected mother to her fetus or newborn and by blood transfusion and organ transplants.
Most people will get infected with the virus during childhood or early adulthood. The majority are without any symptoms but a few may develop fever, sore throat and headache. Once infected, the virus lies dormant in the body forever, with a little risk of getting reactivated. This is known as a recurrent CMV infection.
The drug of choice for treatment of CMV disease is intravenous ganciclovir, although valganciclovir may be used for nonsevere CMV treatment in selected cases. Ganciclovir is a nucleoside analogue that inhibits DNA synthesis in the same manner as acyclovir.
While all members of the herpes virus family are contagious, CMV isn't considered a sexually transmitted infection (STI) like certain forms of herpes simplex are. Additionally, CMV is considered the only member of the herpes virus family to spread directly from mother to child through the placenta during pregnancy.
Primary CMV infection will cause up to 7 percent of cases of mononucleosis syndrome and will manifest symptoms almost indistinguishable from those of Epstein-Barr virus-induced mononucleosis. CMV, or heterophil-negative mononucleosis, is best diagnosed using a positive IgM serology.
People with CMV may pass the virus in body fluids, such as saliva, urine, blood, tears, semen, and breast milk. CMV is spread from an infected person in the following ways: From direct contact with saliva or urine, especially from babies and young children. Through sexual contact.
You have a weakened immune system and you're experiencing symptoms of CMV infection. For people who have weakened immune systems, CMV infection can be serious or even fatal. People who have undergone stem cell or organ transplants seem to be at greatest risk.
While all members of the herpes virus family are contagious, CMV isn't considered a sexually transmitted infection (STI) like certain forms of herpes simplex are. Additionally, CMV is considered the only member of the herpes virus family to spread directly from mother to child through the placenta during pregnancy.
Although the virus is not highly communicable, it can be spread from person to person by direct contact. The virus is shed in the urine, saliva, semen and to a lesser extent in other body fluids. Transmission can also occur from an infected mother to her fetus or newborn and by blood transfusion and organ transplants.
P35.1 is a billable ICD code used to specify a diagnosis of congenital cytomegalovirus infection. A 'billable code' is detailed enough to be used to specify a medical diagnosis.
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
Where cCMV infection is suspected, or to differentiate from other congenital infections such as CZS, the diagnosis of cCMV in an infant must include NAATs of saliva, urine or both within the first three weeks of life.
Most people are infected at some point during their lifetime. CMV is transmitted through close person-to-person contact with infected secretions, including urine , saliva , blood transfusions , semen, cervical secretion and breast milk. Women caring for children (such as mothers and teachers) are at high risk as infected children can shed the virus in their urine and saliva for months and even years after infection. Congenital cytomegalovirus infection (cCMV) occurs when the virus crosses the placenta during pregnancy and infects the fetus. The highest risk of fetal infection is among mothers experiencing a primary infection during the first and second trimesters of pregnancy. Fetal transmission can also occur if a pre-existing infection is reactivated during pregnancy (i.e. non-primary infection) or if the mother is infected with a new strain of CMV; however, the risk of transmission is much lower. Higher rates of cCMV also occur in the offspring of women who are immunocompromised; for example, due to HIV infection. The prevalence of cCMV infection ranges from 0.2–0.7% of live births in high-income regions to 1–6% in low- and middle-income regions.
Although calcifications due to cCMV can be seen in the basal ganglia and brain parenchyma, concentrated calcifications in the periventricular regions are typical.
Laboratory: Infant testing. Where cCMV infection is suspected, or to differentiate from other congenital infections such as CZS, the diagnosis of cCMV in an infant must include NAATs of saliva, urine or both within the first three weeks of life.
Although calcifications due to cCMV can be seen in the basal ganglia and brain parenchyma, concentrated calcifications in the periventricular regions are typical.
The prevalence of cCMV infection ranges from 0.2–0.7% of live births in high-income regions to 1–6% in low- and middle-income regions.
The highest risk of fetal infection is among mothers experiencing a primary infection during the first and second trimesters of pregnancy. Fetal transmission can also occur if a pre-existing infection is reactivated ...
Cytomegalovirus (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Human and monkeys serve as natural hosts.
Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis.
We are constantly working on adding new ICD code explanations. Please check this page again soon.
This information is not intended for self-diagnosis and does not replace professional medical advice from a doctor.
Provided by the non-profit organization “Was hab’ ich?” gemeinnützige GmbH on behalf of the Federal Ministry of Health (BMG).
Cytomegalovirus (CMV) is a very common herpesviridae virus. Most people will be infected at some point during their lifetime. CMV is transmitted through close person-to-person contact with infected secretions, including urine, saliva, blood transfusions, semen, cervical secretion and breast milk. Congenital cytomegalovirus infection (cCMV) occurs when the CMV crosses the placenta during pregnancy and infects the fetus. The highest risk of fetal infection is among mothers experiencing a primary infection during the first or second trimester of pregnancy. Women who are immunocompromised – for example, with HIV infection – have higher rates of fetal transmission.
Long-term sequelae: While the majority of infants born with cCMV will not have any long-term sequelae, 10–20% will go on to have neurodevelopmental disabilities, including sensorineural hearing loss, epilepsy, cerebral palsy, visual impairment and learning difficulties.
The highest risk of fetal infection is among mothers experiencing a primary infection during the first or second trimester of pregnancy.
CMV infection is very common and in most healthy people presents with mild flu-like symptoms or is asymptomatic (subclinical infection).