what is the icd 10 code for mitrochondrial m2 antibody

What is the antimitochondrial m2 antibody test?

This test looks for substances called antimitochondrial antibody and antimitochondrial M2 antibody in your blood. These substances are usually made by your body if you have a condition called primary biliary cirrhosis (PBC). PBC is the most common autoimmune disease that affects the liver.

What is the optimal result for the antimitochondrial antibody test?

Optimal Result: 0 - 20 Units. This test looks for substances called antimitochondrial antibody and antimitochondrial M2 antibody in your blood. These substances are usually made by your body if you have a condition called primary biliary cirrhosis (PBC). PBC is the most common autoimmune disease that affects the liver.

What is the ICD 10 code for mitochondrial metabolism disorder?

Mitochondrial metabolism disorder, unspecified. E88.40 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2019 edition of ICD-10-CM E88.40 became effective on October 1, 2018.

How specific is mitochondrial m2 antibody for PBC?

Mitochondrial M2 antibody has an even higher specificity for PBC. Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.

What is a mitochondrial M2 antibody?

Anti-mitochondrial M2 antibody (AMA-M2) is specific to primary biliary cirrhosis (PBC), but can also be found in certain patients with autoimmune hepatitis (AIH). Effective methods of differentiating between PBC and AIH are required, as their clinical course and management are different.

Is mitochondrial antibody the same as AMA?

Antimitochondrial antibodies (AMA) are substances (antibodies) that form against mitochondria. The mitochondria are an important part of cells. They are the energy source inside the cells. These help the cells work properly.

What is mitochondrial antibody screening?

A mitochondrial antibody test is used to determine the presence of mitochondrial antibodies which can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of primary biliary cirrhosis (PBC).

What is mitochondrial M2 AB IgG?

Mitochondria M2 Antibody (IgG), EIA - Mitochondrial antibody is present in approximately 95% of patients with Primary Biliary Cirrhosis (PBC). Mitochondrial M2 antibody has an even higher specificity for PBC.

What does a positive mitochondrial antibody mean?

A positive AMA means that there are detectable levels of antibodies in the bloodstream. Although a positive AMA test is most often associated with PBC, it can also be positive in autoimmune hepatitis, lupus, rheumatoid arthritis, and graft-versus-host disease.

What is normal mitochondrial antibody?

Understanding results ofAnti-Mitochondrial Antibody (AMCA) Reference Range. Interpretation. 20.0 Units or less: Negative. 20.1-24.9 Units: l.

What's the difference between PBC and PSC?

Unlike PSC, PBC does not share an association with IBD, colonic cancer or bile duct cancer; however people with PBC with advanced disease can develop liver cancer (HCC), similarly to people with liver cirrhosis from other causes.

What is mitochondrial antibody with reflex to titer?

Mitochondrial Antibody with Reflex to Titer - A high Anti-Mitochondrial Antibody (AMA) titer supports the diagnosis of primary biliary cirrhosis (PBC). Low titers of AMA may be detected in other liver disorders, which include chronic active hepatitis and cryptogenic cirrhosis.

Does AMA always mean PBC?

An AMA test result is considered normal when it doesn't detect any AMAs. But testing negative doesn't always rule out the disease either. Five to 10 percent of people with PBC don't have AMAs in their blood. Those results will usually be taken into account along with other tests and symptoms you're experiencing.

What does M2 positive mean?

What does the test result mean? A high AMA or AMA-M2 level (titer) in the blood indicates that the most likely cause of symptoms and/or liver damage is PBC. The level of AMA is not related to the severity of PBC symptoms or to a person's prognosis.

Can you be AMA positive and not have PBC?

It is rare that a person without the condition will have a positive result. However, some people with a positive test for AMA and no other sign of liver disease may progress to PBC over time. Rarely, abnormal results may also be found that are due to other kinds of liver disease and some autoimmune diseases.

What is PBC blood test?

The test is most often used to detect an autoimmune condition known original known as primary biliary cholangitis, now known as primary biliary cholangitis (PBC). The condition known as PBC destroys the mitochondria in the small bile ducts of the liver.

Expected Turnaround Time

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Clinical Significance

Mitochondria M2 Antibody (IgG), EIA - Mitochondrial antibody is present in approximately 95% of patients with Primary Biliary Cirrhosis (PBC). Mitochondrial M2 antibody has an even higher specificity for PBC.

Test Resources

Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.

What is this test?

This test looks for substances called antimitochondrial antibody and antimitochondrial M2 antibody in your blood.

What other tests might I have along with this test?

Your healthcare provider may also order other tests to confirm that you have PBC. These tests include:

What do my test results mean?

Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.

How is this test done?

The test requires a blood sample, which is drawn through a needle from a vein in your arm.

Does this test pose any risks?

Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.

How do I get ready for this test?

You don't need to prepare for this test. But be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illegal drugs you may use.