icd 10 code for bcr abl1 pcr b

Full Answer

What is the CPT test for BCR ABL1?

BCR-ABL1 Transcript Detection for Chronic Myelogenous Leukemia (CML) and Acute Lymphocytic Leukemia (ALL), Quantitative TEST: 480481 CPT: 81206; 81207

What is the ICD 10 code for BCR positive chronic myeloid leukemia?

2018/2019 ICD-10-CM Diagnosis Code C92.10. Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission. 2016 2017 2018 2019 Billable/Specific Code.

How is BCR-ABL1 quantified using PCR?

The PCR primers and probes are specific for BCR-ABL1 e13a2, e14a2 and e1a2 fusion transcripts. The ABL1 transcript is amplified as the control for cDNA quantity and quality. Serial dilutions of a validated positive control RNA with known t (9;22) BCR-ABL1 are used as reference for quantification of BCR-ABL1 relative to ABL1.

How is BCR-ABL1 quantified relative to ABL1?

Serial dilutions of a validated positive control RNA with known t (9;22) BCR-ABL1 are used as reference for quantification of BCR-ABL1 relative to ABL1. The numeric BCR-ABL1 level is reported as % BCR-ABL1/ABL1 and the detection sensitivity is 4.5 log below the standard baseline (<0.0032%).

What does P210 BCR-ABL1 mean?

The BCR-ABL1 can produce proteins of differing sizes and weights, depending on where the break in chromosome 22 occurred. In CML, the breakpoint in BCR is almost always in the major breakpoint cluster region (M-BCR), leading to the production of BCR-ABL1 protein of a larger size (the protein is called p210).

What is BCR-ABL1 test?

A BCR-ABL test is most often used to diagnose or rule out chronic myeloid leukemia (CML) or a specific form of acute lymphoblastic leukemia (ALL) called Ph-positive ALL. Ph-positive means a Philadelphia chromosome was found. The test is not used to diagnose other types of leukemia.

What is CPT code for BCR-ABL test?

CPT codes 81206, 81207, and 81208 may only be reported when performed as a single test. To submit a claim for BCR-ABL translocation analysis by NGS, use CPT 81479 and one (1) UOS with the assigned DEX Z-code. To report the FDA-approved MRDx BCR-ABL Test use the CPT code 0040U.

What does BCR-ABL1 negative mean?

Atypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome/myeloproliferative neoplasm for which no current standard of care exists. The blood smear of patients with aCML showed prominent immature granulocytosis, and granulocytic dysplasia.

What does ABL1 stand for?

Tyrosine-protein kinase ABL1Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.

Is BCR-ABL the same as Philadelphia chromosome?

Philadelphia chromosome. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The BCR-ABL gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the Philadelphia chromosome.

What is BCR-ABL1 gene rearrangement quantitative PCR?

BCR-ABL1 Gene Rearrangement, Quantitative, PCR - The Philadelphia Chromosome (Ph) is a translocation between chromosome 9 and 22 t(9; 22) (q34; Q11) that is found in more than 90-95% of chronic myeloid leukemia (CML), and in 20-25% of adult and 2-10% of childhood acute lymphoblastic leukemia (ALL).

Is CPT code 81206 genetic testing?

CPT® 81206, Under Genetic Analysis Procedures The Current Procedural Terminology (CPT®) code 81206 as maintained by American Medical Association, is a medical procedural code under the range - Genetic Analysis Procedures.

What is ABL copy number?

The absolute copy number of the target sequence (BCR-ABL) or a control gene (ABL) in an unknown sample can then be calculated using a calibration curve prepared from a set of BCR-ABL RNA standards, and results are expressed as a BCR-ABL/ABL ratio.

What is BCR-ABL1 translocation?

BCR-ABL1, for example, refers to the fusion gene resulting from a reciprocal translocation that joins the ABL1 gene from chromosome 9 to the BCR gene on chromosome 22 and is necessary for the development of chronic myeloid leukemia (CML) (Van Etten, 2019).

Is BCR-ABL a tumor suppressor gene?

Normal ABL1 is a tumor suppressor in BCR-ABL1–induced leukemia.

What is atypical chronic myeloid leukemia?

Atypical chronic myeloid leukemia (aCML) is a blood and bone marrow cancer. A person with aCML has a disorder in the bone marrow cells responsible for producing blood cells, but doctors do not know why this happens. Myelodysplastic/myeloproliferative (MDS/MPN) neoplasms are a group of blood and bone marrow diseases.

At a Glance

To help diagnose and monitor the treatment of chronic myelogenous leukemia (CML) and a type of B-cell acute lymphoblastic leukemia (ALL)

What is being tested?

BCR-ABL1 refers to a gene sequence found in an abnormal chromosome 22 of some people with certain forms of leukemia. Unlike most cancers, the cause of chronic myelogenous leukemia (CML) and some other leukemias can be traced to a single, specific genetic abnormality in one chromosome.

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General Information

CPT codes, descriptions and other data only are copyright 2021 American Medical Association. All Rights Reserved. Applicable FARS/HHSARS apply.

CMS National Coverage Policy

Title XVIII of the Social Security Act, §1833 (e), prohibits Medicare payment for any claim lacking the necessary documentation to process the claim.

Article Guidance

The information in this article contains billing, coding or other guidelines that complement the Local Coverage Determination (LCD) for MolDX: Genetic Testing for BCR-ABL Negative Myeloproliferative Disease L36117.

Bill Type Codes

Contractors may specify Bill Types to help providers identify those Bill Types typically used to report this service. Absence of a Bill Type does not guarantee that the article does not apply to that Bill Type.

Revenue Codes

Contractors may specify Revenue Codes to help providers identify those Revenue Codes typically used to report this service. In most instances Revenue Codes are purely advisory. Unless specified in the article, services reported under other Revenue Codes are equally subject to this coverage determination.

General Information

CPT codes, descriptions and other data only are copyright 2021 American Medical Association. All Rights Reserved. Applicable FARS/HHSARS apply.

CMS National Coverage Policy

Title XVIII of the Social Security Act, §1833 (e), prohibits Medicare payment for any claim lacking the necessary documentation to process the claim.

Article Guidance

The following coding and billing guidance is to be used with its associated Local Coverage Determination.

Bill Type Codes

Contractors may specify Bill Types to help providers identify those Bill Types typically used to report this service. Absence of a Bill Type does not guarantee that the article does not apply to that Bill Type.

Revenue Codes

Contractors may specify Revenue Codes to help providers identify those Revenue Codes typically used to report this service. In most instances Revenue Codes are purely advisory. Unless specified in the article, services reported under other Revenue Codes are equally subject to this coverage determination.

What is BCR ABL1?

BCR-ABL1 Transcript Detection for Chronic Myelogenous Leukemia (CML) and Acute Lymphocytic Leukemia (ALL), Quantitative 1 Acute Lymphocytic Leukemia, BCR-ABL1 Transcript Detection by RT-PCR, Quantitative 2 Chronic Myelogenous Leukemia, BCR-ABL1 Transcript Detection by RT-PCR, Quantitative 3 Quantitative BCR-ABL1 Translocation Detection by RT-PCR for CML and ALL

What is the sensitivity of the BCR-ABL1 assay?

In vitro studies have indicated that this assay has an analytical detection sensitivity of 4.5 log below the standard baseline (<0.0032%). A negative result does not rule out the presence of low levels of BCR-ABL1 transcript below the level of detection of this assay, or the presence of rare BCR-ABL1 transcripts not detected by the assay.

Diagnostic Confirmation

This histology can only be determined by positive genetics and/or immunophenotyping, diagnostic confirmation will always be 3.

Definition

B-lymphoblastic leukemia / lymphoma (B-ALL/LBL) is a neoplasm of lymph oblasts committed to the B-cell lineage that lack the BCR-ABL1 translocation but show a pattern of gene expression very similar to that seen in ALL with BCR-ABL1.

Sources

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020