INTRODUCTION. The term "immune reconstitution inflammatory syndrome" (IRIS) describes a collection of inflammatory disorders associated with paradoxical worsening of preexisting infectious processes following the initiation of antiretroviral therapy (ART) in HIV-infected individuals [1-6].
Immune reconstitution inflammatory syndrome (IRIS) is a state of hyperinflammatory response that usually occurs in the first six months of treatment of HIV/AIDS patients. It is a potential complication of the use of highly active antiretroviral therapy (HAART).
Immune Reconstitution Syndrome, Immune Restoration Disease. In HIV infection, an exaggerated inflammatory reaction to a disease-causing microorganism that sometimes occurs when the immune system begins to recover following treatment with antiretroviral (ARV) drugs.
In cases of severe IRIS not caused by Kaposi's sarcoma or Cryptococcus, corticosteroids are usually the treatment of choice. The recommended dose has not been standardized; this Committee recommends 1 to 2 mg/kg daily of prednisone or the equivalent for 1 to 2 weeks, followed by a taper.