Lusher, J.M.: Recombinant Factor VIIa (NovoSeven®) in the Treatment of Internal Bleeding in Patients with Factor VIII and IX Inhibitors, Haemostasis 1996; 26 (suppl 1): 124-130. 9. Lusher, J.M., et al.: A randomized, double-blind comparison of two dosage levels of recombinant factor VIIa in the treatment of joint, muscle and mucocutaneous
congenital FVII deficiency NovoSeven should be administered to patients only under the supervision of a physician experienced in the treatment of bleeding disorders. CONTRAINDICATIONS NovoSeven®Coagulation Factor VIIa (Recombinant) should not be administered to patients with
N95.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM N95.1 became effective on October 1, 2021. This is the American ICD-10-CM version of N95.1 - other international versions of ICD-10 N95.1 may differ.
CONTRAINDICATIONS NovoSeven®Coagulation Factor VIIa (Recombinant) should not be administered to patients with known hypersensitivity to NovoSeven or any of the components of NovoSeven. NovoSeven is
This medication is used to treat and prevent bleeding in people with certain conditions (such as hemophilia type A or B, low levels of factor VII, Glanzmann's thrombasthenia).
FEIBA (factor VIII inhibitor-bypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor VIIa (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors.
NovoSeven is a novel product and contains activated recombinant DNA human coagulation factor VII (rFVIIa). The recombinant molecule is produced in baby hamster kidney (BHK) cells. Recombinant FVIIa is almost identical to human plasma FVIIa except for a difference in glycosylation.
Factor VII, also called proconvertin, is one such clotting factor produced by the liver. It requires vitamin K for its production. Along with other clotting factors and blood cells, it promotes blood clotting at the site of an injury. It forms normal blood clots and closes the wound to prevent blood loss.
Bypassing Agents: Special blood products, called bypassing agents, are used to treat bleeding episodes for people with high titer inhibitors. Instead of replacing the missing factor, they go around (or bypass) the factors that are blocked by the inhibitor to help the body form a normal clot.
NovoSeven, a protein, controls bleeding in hemophiliacs by stimulating the body's natural clotting mechanisms. It is very similar to human factor VIIa, which is crucial in the series of reactions that cause blood to clot (also called the coagulation cascade).
The new NovoSeven RT provides the same safety and efficacy as the original NovoSeven(R)-but it can be transported and administered quickly.” NovoSeven RT has been manufactured to be room temperature stable (from 36 degrees F to 77 degrees F outside a refrigerator).
First, invert the NovoSeven® RT vial and slowly draw the solution into the syringe. Next, detach the syringe from the vial adapter by turning the syringe counterclockwise. Attach the syringe to the luer end of an infusion needle set. Then, inject the reconstituted NovoSeven® RT intravenously slowly over 2 to 5 minutes.
No human serum or other proteins are used in the production or formulation of NovoSeven. NovoSeven is supplied as a sterile, white lyophilized powder of rFVIIa in single-use vials.
Factor VII deficiency was first described in the medical literature by Dr. Alexander, et al. in 1951 and was referred to as prothrombin conversion accelerator deficiency. The disorder has also been known as Alexander's disease.
Recombinant activated factor VII (rFVIIa) binds to exposed tissue factor at the place of tissue and vascular injury. Thrombin generated by this process activates platelets and the coagulation cascade. It has been used in controlling hemorrhage from surgery, trauma, and other causes with success.
It can be caused by liver disease or by blood cell disorders such as myeloma or aplastic anemia . Acquired factor VII deficiency can also be caused by certain drugs such as medicines that prevent clotting, or by a deficiency of vitamin K.
Lower volume means fast infusion. Because it's a low-volume treatment, NovoSeven® RT takes 2 to 5 minutes to infuse. Administer as a slow bolus injection over 2 to 5 minutes, depending on the dose administered.
The cost for NovoSeven RT intravenous powder for injection (1000 mcg (1 mg)) is around $2,624 for a supply of 1000 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
This is a costly medication (retail price is approximately $2000) that is currently only given to a minority of patients [1,2].
Manufacturer: Biogen Idec, Inc.